The effect of capsaicin on TBARS and TAS in rats with hypothyroidism

In this study, capsaicin was administered to rats with experimental hypothyroidism. İt aimed determine the changes in plasma levels of thiobarbituric acid reactive substances (TBARS), which are indicators oxidative stress, and total antioxidant capacity (TAS), is one components defence mechanisms. A 32 healthy male Wistar Albino weighing 300-350 g, approximately 12 weeks old, were used as animal material study. Rats divided into four equal groups control (K), Capsaicin (C), Hypothyroid (H) + (CH). During 30-day trial period, (10mg / kg day) group C by oral gavage per animal. H, 6-n-propyl-2-thiouracil (PTU) added daily their drinking water at 0.05% weight/volume (W/V). CH group, 10 mg/kg/day method weight volume (W V) PTU water. At end application, we obtained serum samples from subjects under general anaesthesia (thiopental anaesthesia, 40 mg/kg) taking sufficient amount blood heart cardiac puncture. We determined thyroid-stimulating hormone (TSH), triiodothyronine (TT3), free T3 (fT3), thyroxine (TT4) T4 (fT4) samples, TBARS TAS samples. conclusion, light data that lipid peroxidation stress occur However, concluded application partially maintain oxidant/antioxidant balance.